Stiripentol is actually a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates coadministered with stiripentol for greater or reduced outcomes. CYP3A4 substrates may perhaps need dosage adjustment.
As a result, these opportunity future apps should be considered as owning “insufficient proof” until far more added study is carried out — Particularly lengthy-expression scientific reports in large samples of human clients.
istradefylline will enhance the stage or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
In addition, There's also some fears about its prospective unfavorable extensive-term effects: one example is, some early studies have raised considerations that extended-expression usage of modafinil may impair certain cognitive procedures (for instance
This medication includes an extra patient simple fact sheet named a Medication Guidebook. Browse it with treatment. Examine it once more every time modafinil is refilled. When you have any questions about modafinil, please talk with the medical professional, pharmacist, or other wellness treatment provider.
Avoid or substitute One more drug for these remedies when feasible. Appraise for lack of therapeutic impact if medication have to be coadministered. Modify dose In accordance with prescribing information and facts if wanted.
Shift-perform sleep condition is really a circadian rhythm disturbance that usually occurs in people who have to operate for the duration of a time when they'd usually be sleeping. It is principally characterized by too much sleepiness throughout Doing work hrs, and insomnia through sleeping several hours.
EDS and fatigue are remarkably commonplace signs and symptoms, specifically in primary treatment and specialty medicine. They have got overlapping capabilities, which may add to imprecise analysis and inappropriate procedure. Generally speaking, EDS is depicted as drowsiness, snooze propensity and reduced alertness even though fatigue is commonly called weariness, weak spot and depleted energy [forty nine]. Our Major investigation question was aimed toward assessing the effects of modafinil on tiredness and EDS associated with neurological Ailments and its basic safety. This evaluate discovered 10 RCTs about PD, MS, TBI, and PPS during which a complete of a hundred and twenty clients with PD, 234 with MS, one hundred fifteen with TBI and 66 with PPS had been enrolled.
rifapentine will reduce the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Although modafinil has a variety of somewhat nicely-supported health-related utilizes when administered by experienced medical professionals, There are a variety of things that Medical practitioners may look for That may disqualify another person from getting modafinil cure (as a result of elevated risk read more of adverse aspect-outcomes or other adverse reactions).
fosphenytoin will minimize the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
In South Africa, modafinil is Routine V material, meaning that it's authorized to make use of modafinil in South Africa, but only with a sound prescription from the licensed clinical practitioner.[211]
Although the evidence for these various “improvement” effects is generally really weak, illegal abuse of modafinil carries on being increasingly prevalent between experts and pupils.
This client also experienced a serious withdrawal syndrome right after stopping modafinil use, and documented a variety of signs or symptoms together with exhaustion, anxiety, and also the lack of the ability to feel satisfaction (